这篇据说是官方解决方案,貌似很多正版用户也遇到这个错误,我也遇到了,不过还没试过这个方法行不行.以下是原帖:
Does your Mass Effect PC install process crap out because of corrupted files, even when installing from the retail DVD? Does it spit out moronic error messages about the non-existent saferun.exe and saferun.dll? About ready to return the game for a refund? If so, hold up, because BioWare has released a rather complicated workaround to bypass their majorly screwed installer:

You will need:
1) access to the contents of the data directory (either off CD, download, temp files, etc)
2) WinRar or 7zip or any tool that can extract .rar files.
Steps:
1) Create a folder on your system somewhere. Default for the installer is "C:\Program Files\Mass Effect\" or a games folder.
2) Open each .rar file in the utility chosen (WinRar for e.g.)
3) Extract each .rar file into this folder. If you are using an English build, you won't need to extract any .rar file that has a different language code (_es, _fr, _de, _it, etc)
4) After extracting all files, your folder should look like this:
...\Mass Effect\Binaries\
...\Mass Effect\BioGame\
...\Mass Effect\data\
...\Mass Effect\docs\
...\Mass Effect\Engine\
...\Mass Effect\MassEffectLauncher.exe

5) Run the MassEffectLauncher.exe and quit immediately.
6) Run the "Mass Effect (tm)_code.exe" from the data folder. Enter your CD Key, click next, it will exit out.
7) Run the Launcher again, hit "Config". under the "Repair" tab, you can re-create your shortcuts if running XP. If running Vista, I'm sorry, you can't add the game to the Game Explorer in these instructions.
9) Quit back to the launcher.
10) Play! (everything should work nicely now)

简单说就是一个个解压出来,然后进入启动程序,退出,输入序列号,重新启动,建立快捷方式,然后就可以玩了...这个问题不涉及破解...买了正版玩不了的可以看看

支持你一下~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~